Remark: Barbiturates could enhance adverse effects, which include respiratory melancholy, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates raise metabolism and reduce blood concentrations of TCAs.
Drugs that have stage therapy linked with Every single prescription. This restriction usually demands that certain standards be met just before acceptance for that prescription.
pentobarbital will minimize the level or impact of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will lower the level or influence of capivasertib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Powerful or moderate CYP3A inducers reduce capivasertib exposure, which can reduce efficacy.
pentobarbital will minimize the level or result of vinblastine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.
pentobarbital will lessen the level or outcome of solifenacin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
Monoamine oxidase inhibitors (MAOI) may inhibit barbiturate metabolism and lengthen barbiturate effects; watch closely
Reserve concomitant prescribing of those drugs in people for whom other check here remedy options are inadequate. Restrict dosages and durations to the least needed. Keep an eye on intently for indications of respiratory melancholy and sedation.
pentobarbital will lower the level or effect of sunitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will minimize the extent or outcome of celecoxib by influencing hepatic enzyme CYP2C9/10 metabolism. Minimal/Significance Unidentified.
pentobarbital will decrease the level or effect of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead into a lower in fentanyl plasma concentrations, deficiency of efficacy or, probably, advancement of a withdrawal syndrome inside a patient that has formulated Actual physical dependence to fentanyl.
Drugs that require prior authorization. This restriction involves that particular medical standards be achieved before the acceptance on the prescription.
pentobarbital will reduce the extent or outcome of etravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will lessen the extent or result of paclitaxel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.